Core Facility Spotlight: Biomolecular
Screening and Drug Discovery
Searching for compounds to produce new or better drugs is like looking for a
needle in a haystack, with inefficient screening for identification and characteriza-
tion of effective new drug compounds directly impacting the cost of
drug development (now in excess of $1 billion per drug).
The Biomolecular Screening and Drug Discovery (BSDD) facility
located in the Bindley Bioscience Center develops high throughput
approaches to very rapidly assess tens of thousands of compounds
using multiple techniques. Evaluation of several features more efficiently identifies compounds with potential to be effective new pharmaceuticals. BSDD expertise provides researchers with capabilities to
create new approaches to discover biological, synthetic and natural
compounds that can lead to new drugs. Scientific approaches include
drug design and synthesis with novel chemistries; analysis and computational modeling of potential drug candidates; and high throughput
screening and cloning for evaluating response of cells to drugs. The
facility also is open to test new company products and instruments.
Graduate and undergraduate students from the
Departments of Chemical Engineering, Chemistry, Medicinal Chemistry & Molecular Pharmacology, Computer Science and Biological Sciences,
among others, commonly participate in research
within the BSDD Furthermore, BSDD’s established collaborations with several scientific groups
and technology partners represent important
opportunities for both on- and off-campus partners. Collaborative partners have their materials
and ideas tested on a large scale, while academic
researchers can gain access to materials and
information. These collaborations have already
produced patented items.
» high-speed robotic instruments to test thousands of compounds daily;
» chemical compounds collection of around 200,000 unique entities.
» assay development to increase information gained from each screening run;
» computational systems to enable real-time, complex data selection of most
relevant data for analysis;
» collections of expression vectors and bacterial strains;
» web-based flowchart of vectors and protocols; and
» scientific and technical assistance.
To schedule equipment use or for more information, contact Larisa Avramova at
firstname.lastname@example.org or (765) 496-3102. You also may schedule through the Resource
Allocation Tracking online reservation system at http://bit.ly/1wkSRhi.
demonstrates use of the
high speed robot for
and automated assays.